What is a Clinical Trial?

Clinical trials are research studies conducted with people affected by HAE to evaluate whether a drug is safe and effective in humans. They are one of the final stages of the medical research and development process and follow strict standards to protect people. Clinical trials for investigational drugs typically go through 3 phases before the FDA reviews and approves them.

Clinical Trial Steps

Clinical trials are a critical part of drug development and are required before a treatment can be approved by the Federal Drug Administration (FDA) and become available by prescription.

Active Clinical Trials

Please return to this page often to check for clinical trial updates. Contact any of the HAE Advocates to learn about the eight FDA-approved HAE therapies currently available that can transform the lives of people with HAE

KONFIDENT (Kalvista Pharmaceuticals)
1 ongoing study
PHASE 3
Adults (12+ years)
diagnosed with
HAE Type I and II
OASIS-HAE Plus (IONIS Pharmaceuticals)
1 ongoing study
PHASE 3
Adolescents and adults
(12+ years) diagnosed with HAE
RAPIDe-3 (Pharvaris)
1 ongoing study
PHASE 3
Adults (12-75 years)
diagnosed with
HAE Type I and II
CSL312_3003 (CSL Behring)
1 ongoing study
PHASE 3
Adolescents (2-11 years)
diagnosed with
HAE Type I and II
HAELO (Intellia)
1 ongoing study
PHASE 3
Adults 18 and older
diagnosed with
HAE Type I and II

Are You Interested in Participating in a Clinical Trial?

If you are interested in participating in a clinical trial, please click below to contact Christine Selva to see if there is an active clinical trial site in your area.

Ensure you include the following information in your submission:
  • Name
  • Age
  • Location
  • HAE Type
  • Clinical Trial Name
Please contact Christine Selva by e-mail.

Other Ways to Participate in Research


JOIN THE ADVANCE HAE SCIENTIFIC REGISTRY